Caspase 10 anticorps (AA 505-521)

N° du produit ABIN1886883

Cet anticorps anti-Caspase 10 est un anticorps Lapin Polyclonal détectant Caspase 10 dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour Caspase 10 anticorps (AA 505-521) (ABIN1886883)

Antigène: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Caspase 10 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-Caspase 10 anticorps

Épitope: AA 505-521

Specificité: Antibody only recognizes FLICE2 form of caspase-10.

Purification: Purified by DEAE column

Immunogène: Peptide corresponding to amino acids 505 to 521 of human FLICE2.

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Conseil sur la manipulation: Avoid freezing and thawing repeatly.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Détails sur Caspase 10

Antigène: Caspase 10 (CASP10) (Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10))

Autre désignation: Caspase-10

Sujet: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family.A novel ICE/CED-3 protease was identified recently, designated FLICE2 and Mch4 and renamed as caspase-10.Caspase-10 has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits both TNFR1 and CD95 to form complexes with these receptors.Caspase-10 is therefore involved in the CD95 and TNFR1 induced apoptosis.Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8 and -9, which causes the proteolytic cleavage of many key proteins such as PARP.Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death.Caspase-10 is expressed in many tissues and cell lines.
Synonyms: Casp-10, FLICE2

Pathways: Apoptose, Caspase Cascade in Apoptosis